P-320 Change of bone mineral density after long-term use of dienogest with calcium and vitamin D supplementation after surgical treatment of endometrioma

Abstract Study question Does long-term use of dienogest reduce bone mineral density (BMD)? Is ovarian reserve after surgery a risk factor for BMD loss? Summary answer was not significantly changed DNG up to 8years. In patients with minimal changes, postoperative were different. What is known already Dienogest (DNG) promising first-line treatment option the management debilitating endometriosis-associated symptoms. However, there’re some debates about loss treatment. Some studies reported reduction 2-3 years, however, predictive factors found. Hypergonadotropic amenorrhea well osteoporosis. Research on whether function decline associated osteoporosis still lacking. design, size, duration This retrospective study performed 6180 reproductive-aged women who underwent conservative endometriomas and received (2mg/day) prevent recurrence in single center from May 2013 March 2022. Among them, Sixty nine took more than two years followed enrolled this study. Participants/materials, setting, methods taking 24 months 101 laparoscopic operation endometriosis retrospectively analyzed. Calcium vitamins taken as supplements. The changes evaluated every year during by using dual energy X-ray absorptiometry. Pain tumor three operation. For evaluation, age, BMI, size bilaterality, FSH, estradiol AMH levels evaluated. Main results role chance Mean age 39.64 ± 7.59, mean BMI 21.79 3.51 kg/m2. medication 41.33 17.66 (24-101 months). Tumor 5.35 4.29cm. Preoperative 2.81 2.07 ng/mL, 1.78 2.11 1.24 1.26 ng/mL (0.0 - 4.15). level femur 0.8264 0.1201 g/cm2, which different compared baseline (0.8404 0.1194 g/cm2). lumbar spine either (baseline 0.9411 0.1141 post-treatment 0.9477 0.1346 separately). Only 15% showed minimally decreased at (-0.85%), statistically those unchanged group. Although 62.5% decrease spine, either. Postoperative between had reduced both site did not. Limitations, reasons caution As based existing medical records, other that might affect such diet, physical activity could be assessed. Unfortunately, only limited number included most less 2 years. Wider implications findings current contributes enrich literature advantages long term recurrence. Trial registration 2022-07-062